The Best Medicine For Anxiety Disorders SSRIs (selective serotonin reuptake inhibitors) and SNRIs like citalopram (Celexa), Escitalopram (Lexapro), fluoxetine (Prozac), duloxetine (Cymbalta) and Venlafaxine (Effexor XR) are considered to be the first-line treatments for anxiety disorders. Exercise and psychotherapy are important for people with anxiety. Certain doctors prescribe antihistamines, such